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ONCOVET TL (trilostane) Product Description
Indicated for the treatment of pituitary-dependent hyperadrenocorticism in dogs and the treatment of hyperadrenocorticism due to adrenocortical tumor in dogs.
DESCRIPTION: ONCOVET?TL tablets are available in 4 sizes (10, 30, 60 and 120 mg) for oral administration based on body weight. Trilostane (4α,5α-epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile) is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone. This inhibition blocks production of glucocorticoids and to a lesser extent, mineralocorticoids and sex hormones while steroid precursor levels increase. The structural formula is:
INDICATIONS: ONCOVET?TL tablets are indicated for the treatment of pituitary-dependent and adrenal-dependent hyperadrenocorticism in dogs.
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